Month: March 2019

‘GMOs Decoded’ –Krimsky’s latest screed

‘GMOs Decoded’ –Krimsky’s latest screed

GMOs Decoded is Tufts Professor Sheldon Krimsky’s latest skeptical discussion on the virtues of plant biotechnology. Unlike his previous book, The GMO Deception, Krimsky here appears at first to take a more nuanced approach, by taking about eight of his fourteen chapters to explain the details of various biotechnology issues.

The book opens with a Foreword by nutritionist Marion Nestle, which you can read here in her column. Nestle has never been a fan of biotechnology so her comments are fairly anodyne.

Then, in the Introduction, gives away the game by noting that “there is a strong scientific consensus among elites over GMOs.” He goes on to say that “Although some scientists have declared the debate…over,” referencing Jon Entine’s Forbes article which references von Eenennaam and Young’s trillion animal feed study, This major study in the Journal of Animal Science studies feed records for over 100 billion animals fed either GE or non-GE foods, and found no unfavorable effects on the animals.

Then Krimsky notes that “other scientists declare with equal confidence that there is no scientific consensus on GMO safety.” His reference is to a paper in the trivial non-journal Environmental Sciences Europe, by prominent GMO disinformationists: Nicholas DeFarge, Michael Antoniou from Seralini’s group, and Indian pseudo-science mystic Vandana Shiva, among others. The paper presents no research but merely a report on a petition signed by “300 scientists worldwide.” (I have that list and most of the signatories are not scientists.)

The Seralini problem

Critiques of biotechnology, or colloquially “GMOs,” really was heightened by Giles-Eric Seralini’s 2012 paper in Food and Chemical Toxicology featuring tumor-laden Sprague-Dawley rats: Long-term toxicity of Roundup herbicide and a Roundup-tolerant genetically-modified maize.” Even the title made the objective confusing.  Wayne Parrott’s criticism describes the paper’s problems clearly.

The paper had so many problems from animal husbandry to poor experimental design that protests and a re-review caused the journal to withdraw the paper. It was eventually reprinted (without review) in Environmental Sciences Europe where you can find it now.

Seralini’s group has continued to publish papers critical of biotechnology, all of questionable validity, and many very difficult to follow. His co-workers and colleagues have been publishing these papers ever since, and Brazeau has dubbed them the “Seralini pseudo-science syndicate.” And none of his lab’s papers have been replicated be others.

The footnotes

You can learn a great deal about a book’s approach by scanning the footnotes, which occupy pages 156-181 in Krimsky’s book. It doesn’t take long to discover that the footnotes are larded with 15 references to Seralini’s disinformation machine.

Charles Benbrook who was for a few years at Washington State University, but whose salary was paid by the Organic Center and has close ties anti-GMO activists, appears in 5 footnotes, and his paper (published in a predatory pay-to-play journal) claiming negative impacts of GM crops has been roundly debunked by Brookes, Carpenter and McHughen.

Jonathan Latham, publisher and author of the anti-biotech Independent Science News appears twice arguing that transgenic plants can sometimes mutate dangerously. He has been severely criticized by Katiree.

There are, however, many footnotes to well-regarded sources such as Brown and Federoff’s Mendel in the Kitchen and papers by legitimate scientists like Wayne Parrott and Alessandro Nicolia, for example.

The chapters

The book starts out soberly as an outline of various genetic breeding techniques: traditional, molecular and their differences. Chapter 4 details difficulty in producing the Flavr-Savr tomato and FrostBan  bacteria. Chapter 5 covers herbicide resistant  crops and brings up no-till farming, which can improve soil health. However, it suggests that herbicide resistant weeds may require tilling. However, this has obvious solutions in crop rotation. The chapter also brings up Benbrook’s discredited paper claiming increases in herbicide use that are significantly overstated. This chapter also brings up the IARCs discredited claim that glyphosate can cause cancer.

Chapter 6 fairly and accurately covers disease resistant crops, but in Chapter 7 covering insect resistant crops, Krimsky goes afield in his summary of Starlink Corn, spending  several pages scaring us, only to finally report that there was no evidence that Starlink corn caused any illnesses. Krimsky then cites Antoniou and Robinson from Seralini’s stable to claim GM-fed rats suffered liver and kidney damage in a 3-generation study that you can safely ignore.

Chapter 8 on GMO Risk Assessment makes claims that “scientists differ,” but suffers from a dearth of supporting footnotes on who and what these differences are. There is a lot of “some groups” but “other groups” but little supporting explanation.

Chapter 9 on Contested Viewpoints argues that trans-genes may be placed differently and could result in plants having different properties, including varying toxicity, but cites Latham twice and actual scientists in Kuiper et. al. You have to actually check the papers to see that there is little to be concerned about here. He also raises the question of whether pre-market testing is actually done, as if this is not a requirement for approval. Krimsky also gets “substantial equivalence” wrong, but Kuiper explains it clearly.

  • Substantial Equivalence is a starting point for a safety assessment
  • Make a comparison between the GM organism and its closes traditional counterpart.
  • Identify intended or unintended difference on which further safety assessment should be focused.

By contrast, Krimsky says that a transgenic crop and its conventional counterpart about which toxicology information is known are compared. “When extensively analyzed, if the transgenic crop exhibits no changes …compared to its parent strain it can be treated as substantially equivalent to that strain. After that determination is made, further safety or nutritional concerns are expected to be insignificant.”

This is just not the same idea at all!

The chapter also mentions a 13-week pilot study on the effect of Roundup on the gut microbiome of rats in a study performed by the Ramazzini institute in Italy. While they did claim to find some changes in the microbiome, the Ramazzini institute seems to have a spotty reputation, having been criticized for poor reliability in another recent study on aspartame, and in the glyphosate case, Brazeau criticizes them for finding “results that match their priors but not anyone else’s research.” (They also did a questionable report on cell phone radiation.)

Much of the rest of the chapter deals with worries that have never been found to be an actual problem.

Chapter 10 rehashes all the arguments for labeling GMOs and some of the issues various states have encountered, closing with the fact that Congress passed a “labeling law” that amounts to a QR code you can scan with your phone, and is thus pretty harmless.

Chapter 11 deals with the 2016 National Academies Study on Genetically Engineered Crops. Krimsky admits that the evidence of the report reinforces the fact that GM crops are safe to eat and do not pose any risks. However he carefully picks advantageous quotes to suggest that biotechnology does not improve yields. One would wonder why famers are then willing to pay more for them. If you read through the report or its summary you will find a number of carefully written conclusions suggesting that it is mostly difficult to measure the effects of yield because it is difficult to find identical cropland to compare GM and non-GM crops, and whether the GM and non-GM varieties were true isolines to be comparable. The report also discusses the strategy for preventing evolution of herbicide reisistant weeds and Bt resistant insects.

In fact, the report suggests that in the U.S. and in China, insect-pest populations “are reduced regionally and that this benefits both adopters and nonadopters of Bt crops.” And it is important to note that Bt brinjal (eggplant, or aubergine) has significantly improved farmers’ lives in both Bangladesh and India.

Krimsky also spends 3 pages defending Seralini’s disgraced paper, claiming that was “not a carcinogenicity study” to defend the small number of rats used. In fact, critics have said that Seralini’s paper had no particular objective in advance and he let the S-D rats grow until they naturally developed tumors and published their pictures.

Finally, Krimsky attacks the integrity of the NASEM panel itself, pointing to a reference that claims 6 out of 20 members had conflicting financial interests. Of course that paper is by Krimksy himself.

Chapter 12 discusses the development of Golden Rice, which the author calls a “promise unfulfilled.” It has now been approved by the US FDA, however.

Chapter 13 discusses conflict among scientists regarding GMOs as if it actually existed. The overwhelming worldwide consensus, including every major national scientific association, is that GM crops pose no harm. He mentions “uncertain risks,” and the “GMO divide” which he himself has tried to manufacture. He recycles the canard that “farmers do no own their own seeds” as if hybrid seeds had never before existed, and of course mentions international crackpot Vandana Shiva who questions  patenting living organisms. Oh, and don’t forget “corporate hegemonic control.”

Chapter 14 presents Krimsky’s completely expected, but erroneous summation. He attacks the values of science and “trans-scientific concepts,” (whatever they are!). He suggests that “it’s an evolving story in India,” despite the overwhelming success of Bt brinjal, and questions whether yields actually improve. Of course he trots out Robin Mesnage, one of Seralini’s henchmen to argue that corn (maize) sprayed with Roundup produces different metabolites, and claims farmers have untold economic losses because of unexpected GM contamination.


Krimsky starts out soberly enough trying to explain the various techniques that have been developed and some of their successes. But he can’t help himself, and by Chapter 5 he is back beating the same poor old horse, and gradually slipping more misinformation into each succeeding chapter. Nothing really new here, unfortunately.


Sheldon Krimsky publishes more anti-GMO malarkey

Sheldon Krimsky publishes more anti-GMO malarkey

This 2015 review is being republished in advance of my forthcoming review of Krimsky’s latest book.

Sheldon Krimsky, Professor of Humanities & Social Sciences at Tufts University has published another in a series of articles and books attacking the safety of genetically modified plants (GMOs). Professor Krimsky’s appointment is in the Department of Urban & Environmental Policy & Planning, but he holds and adjunct appointment in the Department of Public Health and Community Medicine. Krimsky holds a masters in physics, but his PhD is in philosophy. Thus, many of his arguments have already been rejected by biologists.

Last year Krimsky published The GMO Deception at Skyhorse publishing (who also published RFK jr’s anti-vax book). While the book’s anti-science point of view is obvious from the title, it received a devastating review at Biofortified , who pointed that the book is nothing but a repackaging of old, discredited articles from GeneWatch archives. That site is hosted by the Council of Responsible Genetics, where Krimsky is the chairman.

Getting to Krimsky’s latest publication “An Illusory Consensus behind GMO Health Assessment,” it too brings up a number of discredited articles and workers.

The thesis of Krimsky’s article is that there is not a scientific consensus on the safety of GMOs, because he has uncovered about 26 articles attacking them. Krimsky’s paper is published in the journal Science, Technology and Human Values, where Krimsky is on the editorial board.

In discussing articles on biotechnology, it is useful to remember  The Seralini Rule, published in the Skeptico blog, which states that

If you favorably cite the 2012 Séralini rats fed on Roundup ready maize study, you just lost the argument.

That Skeptico article summarizes all the problems with that discredited and withdrawn paper, noting that if you cite this paper as serious science you haven’t taken the trouble to consider all of its scientific weaknesses.

Unfortunately, Professor Krimsky’s paper fails this test, citing 5 papers by this discredited scientist.

Krimsky’s  article is divided into three parts. In the first part, he summarizes eight recent review articles on GMOs finding some very critical and some much less critical. We read several of the more critical ones to see if we could understand his point.

He first cites “Genetically Modified Foods and Social Concerns,” by Maghari and Ardekani, published in the Iranian journal Avicenna Journal of Medical Biotechnology. This paper is basically a summary of potential concerns, none of which are supported by actual science. Suggesting that transgenic DNA might break up and reintegrate into the genome (which has never been observed), he cites two non-peer-reviewed reports by Mae Wan Ho, who has been criticized for embracing pseudoscience. Even more risible is Maghari’s assertion that GMOs may be responsible for “food-borne diseases” such as the “epidemic of Morgellon’s disease in the U.S.” In fact, Morgellon’s disease is a delusion that one’s skin is crawling when no cause can be found, and is considered a psychiatric ailment, not one caused by diet.

The second paper we read from his list was a literature review by Domingo and Bordonaba, which also violates the Seralini rule, and asserts without proof that studies showing the safety of GMOs have been performed by biotechnology companies. This is in fact contrary to the findings of Biofortified’s GENERA database of papers, which found that more than half of the studies were performed by independent researchers.

The third paper he cites, by Dona and Arvanitouannis also violates the Seralini rule, and completely misstates the doctrine of “substantial equivalence.” The correct statement of this principle is that if a GM and a conventional crop have similar origins, then their “substantial equivalence” can be the starting point for testing of the GM version to see if it has different properties that might make it dangerous to the consumer. It does not mean that no further testing is required. It also erroneously suggests that the Cauliflower Mosaic Virus, which is found on all cauliflower, is dangerous if used in biotechnology. This is, of course, rubbish, since we eat it every day on most brassicae.

In checking these papers, we quickly wander down a “rabbit hole” of papers referring to other papers and to each other, but all seeming to cite the same erroneous information. After citing some inconclusive studies, Krimsky quotes the American Academy of Environmental Medicine, which is listed on QuackWatch, and is not recognized by the American Board of Medical Specialties. It has been criticized by Science Based Medicine, and is considered a dubious certifying board.

Arpad Pusztai and Giles-Eric Seralini

In the second part of his paper Krimsky focuses on the poorly regarded work of Pusztai and of Seralini, carefully omitting some of the more damning details about their work.

Pusztai was asked to evaluate some experimental genetically modified potatoes, and reported that they damaged the stomach lining of rats. After an investigation by his employer, the Rowett Institute, found that his data did not support his conclusions, he was fired. However, Krimsky does not note what Chassy and Tribe have pointed out: the potatoes Pusztai used were an experimental and unapproved variety, and that the rats were fed uncooked potatoes, which are always harmful to rats. Moreover, two expert panels concluded that no scientific conclusions could be drawn from his work. Pusztai has become an anti-GMO activist, travelling the world giving scary talks, but has not carried out any further science.

Professor Giles-Eric Seralini has published a number of papers critical of GMOs, and their confusing style and lack of rigor have been criticized long before his rat tumor paper. However, when Seralini published his 2012 paper, scientists immediately began criticizing its small sample size, lack of double blinding, animal mistreatment, and unsupported conclusions: Sprague-Dawley rats develop tumors anyway, which is why they are suitable for 90 day experiments but not 2-year experiments.

Krimsky notes that Seralini revealed his association with CRIIGEN, a French anti-GMO organization he headed, but did not mention that Seralini’s work was sponsored by Carrefour grocery chain and the Auchan retail group who wanted to promote their new line of organic (non-GMO) products.

When many, many scientists protested to Food and Chemical Toxicology that this paper did not represent good science, the journal editor, A. Wallace Hayes, convened a new group of referees to review the paper. After nearly a year, the review panel concluded that the paper should be withdrawn because of its scientific flaws, and it was. Krimsky fails to mention the panel, but suggests the editor did this unilaterally.

Krimsky also cites an article which suggests that a “new assistant editor” joined the board of Food and Chemical Toxicology who had previously worked for Monsanto. This old conspiracy theory is easily laid to rest: biologist Richard Goodman worked for Monsanto from 1997-2004 and then joined the faculty of the University of Nebraska, long before Seralini’s paper came to light. He was an assistant editor during the Seralini controversy, but Hayes specifically excluded him from the review panel at Seralini’s request.

Author’s Conclusions

Professor Krimsky’s conclusions rely on the fact that he claims to have found 26 animal studies that found “adverse effects or uncertainties of GMOs fed to animals.” We didn’t read all of them, but we have already read some which are discredited and/or published in very low-level journals.

  1. Ewen and Pusztai, “Effects of Diets Containing Genetically Modified Potatoes,’ Discussed above.
  2. Ermakova, “Genetically Modified Soy Leads to the Decrease of Weight and High Mortality of Rat Pups.” Not published in any journal.
  3. Seralini, Cellier and Vendomois, “New Analysis of Rate Feeding Study with GM Maize Reveals Signs of Hyporenal Toxicity.’ The EFSA has debunked this paper.
  4. Aris and LeBlanc, “Maternal and Fetal Exposure to Pesticdes Associated tp GM Foods in Eastern Township of Quebec, CA.” Critiqued by Anastasia Bodnar.
  5. Carman, Vlieger,Ver Steeg, Sneller, Robinson al., A Long-Term Toxicology Study on Pigs Fed a Combined GMO Soy and Maize Diet.” Published on a non-peer-reviewed journal. Bozianu’s work rebutted this paper. Rebutted by Mark Lynas  and  by David Gorski.
  6. Seralini al. “Long Term Toxicity of a Roundup herbicide…” Discussed above, and debunked by Skeptico and by Wayne Parrott.
  7. De Vendomois, Spiroux and Seralini, “A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health” Reviewed and debunked here.



Professor Krimsky has recycled old, discredited papers and arguments as if they were new to try to imply that there is a serious doubt about the safety of GM crops. He neglects the thousands of papers that make up the scientific consensus over the few weak ones he has dredged up to make his point. And Professor van Eenennaam’s billion animal study simply closes the door on this discussion.

Rizzuto’s in Westport is still excellent

Rizzuto’s in Westport is still excellent

We haven’t visited Rizzuto’s excellent restaurant (and oyster bar) in too long, and we are delighted to report that it is better than ever. It’s a risk to visit any restaurant in a Saturday night when they are busiest, but the staff was right on top of everything even though every table was full. They were, thoughtful, fast, efficient and never missed a thing. And the food was outstanding.


One of our appetizers was a Pan Seared Jumbo Crab Cake, Maryland style ($14) which may be the closest we’ve ever had to a Maryland crab cake outside that state. I was meaty, with a spicy, mustardy tang, and was served with an excellent remoulade along with tomatoes, salad green and lemon. Really worth the trip for this one alone.

chowderOur other appetizer was their New England Clam Chowder ($9) served with plenteous clams, potatoes and a bit of bacon. Another ideal starter for your dinner.

On their specials menu that night, they served pan seared Chilean Sea Bass ($36) on a delicious Wild Mushroom Risotto, with asparagus and lobster cream. And yes, there were a few pieces of lobster in it as well. Sea bass has proliferated just about everywhere you go these days, but this sea bass was perfectly cooked: tender, juicy and flavorful. And the lobster sauce topped it to perfection.

sea bass

Our other entrée was also from their nightly specials:  Rigatoni al Forno ($24), baked with  Italian sausage, eggplant, mozzarella, parmigiano Reggiano, plum tomato sauce and fresh basil. This, too, was simply outstanding and so filling we brought some home for lunch.


We had to split a dessert to see what they were like. The one we chose was called Chocolate Truffle Ring Ding ($8) which was chocolate cake with a chocolate cream filling,  chocolate ganache and freshly whipped cream. A nice finish to the meal.


We definitely have to go back there more often, as this was one of our best experiences in some time.